Last year I left WAY too many buds on - so because of that, and the fact that I'm trying to get powdery mildew (PM) under control, I pruned them VERY aggressively. I may have killed some even. But my goal this year is to get healthy vines, not lots of grapes.
Just before, and about a week after in some cases, I sprayed with a dormant spray of Lime Sulfur (1 quart / 3 gallons) to kill any over-wintering PM. I started spraying before final pruning, but quickly realized that was a waste of time, so instead pruned and sprayed about a week after.
In a few weeks, as buds swell, I'll know better how I did!